Anti-ARNT2 Rabbit Polyclonal Antibody for WB and ELISA - Q9HBZ2

Core Product Specifications and Parameters

Biological Background: ARNT2 Function and Localization

• ARNT2 (Aryl hydrocarbon receptor nuclear translocator 2), also known as Class E basic helix-loop-helix protein 1 (bHLHe1), is a transcription factor encoded by the ARNT2 gene in humans.
• Plays a critical role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Related references: PMID:24022475
• Specifically binds to the xenobiotic response element (XRE) to regulate gene expression.
• Localizes to the nucleus, consistent with its role in transcriptional regulation.
• Undergoes methylation, which may modulate its activity.
• Subject to alternative splicing, potentially generating multiple isoforms with distinct functions.
• Contains DNA-binding domains and acts as a key regulator in cellular responses to environmental signals.

Experimental Guidance and Technical Tips

• For Western blotting, a band of approximately 79 kDa is expected. Consider using nuclear extracts or whole-cell lysates from tissues rich in ARNT2, such as brain or kidney.
• Cross-reactivity with mouse and rat allows for translational studies in rodent models; validate reactivity in relevant tissue extracts before large-scale experiments.
• When performing ELISA, optimize antibody concentration and blocking conditions to minimize background; the immunogen spans a large region, which may contribute to high sensitivity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as your comprehensive partner for IVD raw materials, offering a seamless supply chain from antigen design to optimized antibodies. This anti-ARNT2 polyclonal antibody supports research in neuroendocrine development and transcriptional regulation. We provide bulk quantities, validated antibody pairs, and customized sourcing solutions to accelerate your diagnostic assay development.